The Significance of Tablet Internal Structure on Disintegration and Dissolution of Immediate-Release Formulas: A Review

The internal microstructure of a tablet, such as pore geometry and volume, impacts the tablet’s disintegration kinetics. Ideally, one could design to control dissolution onset therapeutical performance immediate-release formulas; however, manufacturing tablets with desired can be challenging due interplay between formulation process parameters. Direct quantification tablet provide framework for optimizing composition parameters based on Quality-by-Design approach. This article reviews importance liquid transport kinetics help optimize release profiles products. Additionally, influencing are discussed.